Publications

 

Bell Lab Publications, Previews & Reviews

Bug in the code: TB blocks DNA repair.

Madduri BTSA, Bell SL. Cell Host Microbe. Preview. 2023 Nov 8;31(11):1769-1771. doi: 10.1016/j.chom.2023.10.012.

 

Previous Publications

Deficiency in Galectin-3, -8, and -9 impairs immunity to chronic Mycobacterium tuberculosis infection but not acute infection with multiple intracellular pathogens.

Morrison HM, Craft J, Rivera-Lugo R, Johnson JR, Golovkine GR, Bell SL, Dodd CE, Van Dis E, Beatty WL, Margolis SR, Repasy T, Shaker I, Lee AY, Vance RE, Stanley SA, Watson RO, Krogan NJ, Portnoy DA, Penn BH, Cox JS. PLoS Pathog. 2023 Jun;19(6):e1011088. doi: 10.1371/journal.ppat.1011088.

 

Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis.

Weindel CG, Martinez EL, Zhao X, Mabry CJ, Bell SL, Vail KJ, Coleman AK, VanPortfliet JJ, Zhao B, Wagner AR, Azam S, Scott HM, Li P, West AP, Karpac J, Patrick KL, Watson RO. Cell. 2022 Aug 18;185(17):3214-3231.e23. doi: 10.1016/j.cell.2022.06.038.

 
 

The opportunistic intracellular bacterial pathogen Rhodococcus equi elicits type I interferons by engaging cytosolic DNA sensing in macrophages.

Vail KJ, Petri da Silveira B, Bell SL, Bordin AI, Cohen ND, Patrick KL, Watson RO. PLoS Pathog. 2021 Sep;17(9):e1009888. doi: 10.1371/journal.ppat.1009888.

 

Elevated type I interferon responses potentiate metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice.

Lei Y, Torres-Odio S, Martinez CG, Bell SL, Birdwell CE, Bryant J, Watson RO, West LC, West AP. Sci Adv. 2021 May;7(22). doi: 10.1126/sciadv.abe7548.

 

Interactions between fungal hyaluronic acid and host CD44 promotes internalization by recruiting host autophagy proteins to forming phagosomes.

Ding S, Pandey A, Feng X, Yang J, da Costa LF, Mouneimne RB, Rice-Ficht A, Bell SL, Watson RO, Patrick KL, Qin Q, Ficht TA, de Figueiredo P. iScience. 2021 Mar 19;24(3):102192; doi: 10.1016/j.isci.2021.102192.

 

TRIM14 is a key regulator of the type I interferon response during Mycobacterium tuberculosis infection.

Hoffpauir CT, Bell SL, West KO, Jing T, Torres- Odio S, Cox JS, West AP, Li P, Patrick KL, Watson RO. J Immunol. 2020 May 13, ji1901511; doi: 10.4049/jimmunol.1901511.

Highlighted by: Top Reads: TRIMming up the IFN response. J Immunol. May 2020.

 

LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to Mycobacterium tuberculosis.

Weindel CG**, Bell SL** (authors contributed equally), Vail KJ, West KO, Patrick KL, Watson RO. eLife. 2020;9:e51071 doi: 10.7554/eLife.51071.

Highlighted by: Wallings RL, Herrick MK, Malú Gámez Tansey MG. Parkinson’s Disease: Linking mitochondria to the immune response. eLife. 2020;9:e56214 doi: 10.7554/eLife.56214.

See also: Weindel CG**, Bell SL**, Huntington TE, Vail KJ, Srinivasan R, Patrick KL, Watson RO. LRRK2 regulates innate immune responses and neuroinflammation during Mycobacterium tuberculosis infection. bioRxiv. 2019 Jul 26. doi: 10.1101/699066.

 

A conserved PLPLRT/SD motif within the C-terminal tail of STING mediates the recruitment and activation of TBK1.

Zhao B, Du F, Xu P, Chang Shu, Sankaran B, Bell SL, Liu M, Lei Y, Gao X, Ji J, West AP, Watson RO, and Li P. Nature. 2019 May 22. doi: 10.1038/s41586-019-1228-x.

 

Quantitative yeast genetic interaction profiling of bacterial effector proteins uncovers a role for the human retromer in Salmonella infection.

Patrick KL*, Wojcechowskyj JA*, Bell SL, Riba M, Jing T, Talmage S, Xu P, Cabello AL, Xu J, Shales M, JimenezMorales D, Ficht TA, de Figueiredo P, Samuel JE, Li P, Krogan NJ, Watson RO. Cell Systems. 2018 Sep 26;7(3):323-338.e6. doi: 10.1016/j.cels.2018.06.010.

 

An Mtb-human protein-protein interaction map identifies a switch between host antiviral and antibacterial responses.

Penn BH, Netter Z, Johnson JR, Von Dollen J, Jang GM, Johnson T, Ohol YM, Maher C, Bell SL, Geiger K, Golovkine G, Du X, Choi A, Parry T, Mohapatra BC, Storck MD, Band H, Chen C, Jäger S, Shales M, Portnoy DA, Hernandez R, Coscoy L, Cox JS, Krogan NJ. Mol Cell. 2018 Aug 16;71(4):637-648.e5. doi: 10.1016/j.molcel.2018.07.010.

 

The cytosolic sensor cGAS detects Mycobacterium tuberculosis DNA to induce type I interferons and activate autophagy.

Watson RO**, Bell SL** (authors contributed equally), MacDuff DA, Kimmey JM, Diner EJ, Olivas J, Vance RE, Stalling CL, Virgin HW, Cox JS. Cell Host Microbe. 2015 June 10;17(6):811-9. doi: 10.1016/j.chom.2015.05.004.

 

The BiP molecular chaperone plays multiple roles during the biogenesis of torsinA, an AAA+ ATPase associated with the neurological disease early-onset torsion dystonia.

Zacchi LF, Wu HC, Bell SL, Millen L, Paton AW, Paton JC, Thomas PJ, Zolkiewski M, Brodsky JL. J Biol Chem. 2014 May 2;289(18):12727-47. doi: 10.1074/jbc.M113.529123.

 

Expression of a malarial Hsp70 improves defects in chaperone-dependent activities in ssa1 mutant yeast.

Bell SL, Chiang AN, and Brodsky JL. PLoS One. 2011;6(5):e20047. doi: 10.1371/journal.pone.0020047.

 

Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum.

Chiang AN, Valderramos JC, Balachandran R, Chovatiya RJ, Mead BP, Schneider C, Bell SL, Klein MG, Huryn DM, Chen XS, Day BW, Fidock DA, Wipf P, Brodsky JL. Bioorg Med Chem. 2009 Feb 15;17(4):1527-33. doi: 10.1016/j.bmc.2009.01.024.

 

Previous Reviews

Exploring the “multiple-hit hypothesis” of neurodegenerative disease: bacterial infection comes up to bat.

Patrick KL, Bell SL, Weindel C, Watson RO. Review. Front Cell Infect Microbiol. 2019 May 28. doi: 10.3389/fcimb.2019.00138.

 

Cytosolic DNA sensing during intracellular bacterial infection induces potent innate immune responses.

Patrick KL**, Bell SL** (authors contributed equally), Watson RO. Review. J Mol Bio. 2016 Apr 29. doi: 10.1016/j.jmb.2016.04.030.